Mesrine: Killer Instinct introduces us to Jacques Mesrine (Vincent Cassel), a loyal son and dedicated soldier back home and living with his parents after serving in the Algerian War. Handsome and charming, he is soon seduced by the neon glamour of sixties Paris and the easy money it presents. Mentored by Guido (Gérard Depardieu), Mesrine soon moves swiftly up the criminal ladder, choosing the high risk life of a gangster over the honest life of the hard working family. After pulling off an audacious heist he and his lover Jeanne (Cécile de France), flee to Canada where the opportunity of one big payout lures him out of hiding and propels him towards international notoriety. The incredible and brutal story of Jacques Mesrine (Vincent Cassel) continues in Mesrine: Public Enemy Number 1.